Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas
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Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas.
Tumor growth is the result of deregulated tissue homeostasis which is maintained through the delicate balance of cell growth and apoptosis. One of the most efficient inducers of apoptosis is the death receptor Fas. We report here that oncogenic Ras (H-Ras) downregulates Fas expression and renders cells of fibroblastic and epitheloid origin resistant to Fas ligand-induced apoptosis. In Ras-trans...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1999
ISSN: 1460-2075
DOI: 10.1093/emboj/18.7.1824